Organic Acids
![Medchemexpress LLC 6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- (TFA) | 99.1% | 597.58 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438226-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- (TFA) | 99.1% | 597.58 | 25 MG
AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. It potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin.
- Potentiates TRPV1 channels activation by protons
- Drives reflectory inhibition of thermogenesis and tail-skin vasoconstriction
- Potently blocks channel activation by capsaicin
Medchemexpress LLC Adrixetinib (TFA) | 2394874-66-7 | C27H25F6N5O7 | 1 ML
Adrixetinib (TFA) is a protein tyrosine kinase (PTK) inhibitor (antagonist) with anti-tumor effects.
- Molecular formula: C27H25F6N5O7.
- Molecular weight: 645.51.
- Appearance: Off-white to light yellow solid.
- Purity (HPLC) of 99.82%.
- Recommended storage at 4°C in sealed conditions, away from moisture.
- When in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month, under sealed conditions and away from moisture.
Medchemexpress LLC Claramine TFA | 3030428-57-7 | 95.0% | 703.02 | 5 MG
Claramine TFA is a steroidal polyamine that regulates the properties of lipid membranes and offers protection to cells against various biological toxins. These toxins include misfolded protein oligomers and those derived from biological proteins.
- Does not affect cell viability in human neuroblastoma cells (sh-sy5y) at concentrations below 10 μM.
- Does not impact cell activity in hek293 cells.
- Protects human neuroblastoma (sh-sy5y) cells from the harmful effects of pore-forming agents, melittin and α-hemolysin, by inhibiting their binding to cell membranes.
Medchemexpress LLC Survodutide TFA | 99.4% | 4231.62 (free base) | 25 MG
Survodutide TFA is a potent and selective dual agonist targeting the glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R), with EC50s of 0.52 nM and 0.33 nM respectively in CHO-K1 cells. This 29-amino-acid acylated peptide, featuring a C18 fatty acid, demonstrates significant anti-obesity efficacy by enhancing energy expenditure and reducing food intake.
- Potent, selective GCGR/GLP-1R dual agonist
- EC50s of 0.52 nM (GCGR) and 0.33 nM (GLP-1R)
- 29-amino-acid acylated peptide
- Contains a C18 fatty acid
- Demonstrates robust anti-obesity efficacy
- Increases energy expenditure and decreases food intake
- Enhanced proteolytic stability
- Extended terminal half-life
Medchemexpress LLC Maurocalcine (TFA) | 95.1% | 3858.55 (free base) | 100 UG
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. It induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. This product exhibits an apparent affinity of 14 nM for RyR2 and can be applied to in vivo cell tracking or other cell imaging techniques.
- Agonist of ryanodine receptor (RyR) channel types 1, 2 and 3
- Exhibits cellular permeability
- Induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM
- Exhibits an apparent affinity of 14 nM for RyR2
- Can be applied to in vivo cell tracking or other cell imaging techniques
Medchemexpress LLC GsMTx4 TFA | 99.9% | 4095.84 | 1 MG
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs) and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity, making it a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels (MSCs)
- Blocks cation-selective stretch-activated channels (SACs)
- Attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity
- Attenuates microglial reactivity
- Useful as a pharmacological tool for identifying the role of excitatory mechanosensitive channels
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 5 MG
Veldoreotide TFA (DG3173) is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and has potential use as a pain modulating agent.
- Activates somatostatin receptors 2, 4, and 5
- Inhibits growth hormone (GH) secretion in adenomas
- May be used as a pain-modulating agent
- Stimulates SST2, SST4, and SST5 receptors in HEK293 cells co-expressing these receptors with GIRK2 channels
- Inhibits SST4-expressing BON-1 cells at 10 μM for 24 hours
Supply Solutions Trifluoroacetic acid | 76-05-1 | 114.02 g/mol | 10x1ml
Trifluoroacetic acid | 76-05-1 | 114.02 g/mol | 10x1ml
Medchemexpress LLC Stressin I TFA | 98.6% | 4472.20 | 5 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist with a Ki of 1.7 nM. It induces an increase in adrenocorticotropic hormone (ACTH) levels in rats. This product is for research use only and not sold to patients.
- Potent CRF1 receptor selective agonist
- Induces increase in adrenocorticotropic hormone (ACTH) levels
- White to off-white solid appearance
- For research use only
Medchemexpress LLC Pepinh-MYD TFA | 1421052-89-2 | 98.9% | 3388.03 | 5 MG
Pepinh-MYD TFA is a MyD88 inhibitor designed to interfere with MyD88-mediated TLR signaling pathways. It contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling cell membrane penetration and inhibition of related immune responses. This compound shows potential for studying the role of MyD88 in viral infections, including COVID-19.
- Acts as a MyD88 inhibitor
- Contains a domain sequence from MyD88 TIR
- Includes a protein transduction sequence for cell membrane penetration
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits immune responses
- Suitable for studying the role of MyD88 in viral infections
- Applicable in COVID-19 anti-virus research
Medchemexpress LLC Stressin I TFA | 98.63% | 4472.20 (free base) | 1 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent and selective agonist for the CRF1 receptor, intended for research use only. It has been shown to increase adrenocorticotropic hormone (ACTH) levels in rats.
- Potent CRF1 receptor selective agonist
- Ki of 1.7 nM
- Increases adrenocorticotropic hormone (ACTH) levels in rats
Medchemexpress LLC Glycyl-Exatecan (TFA) | 1883333-57-0 | 96.9% | 25 MG
Glycyl-Exatecan TFA (Glycyl-DX-8951 TFA) is an anticancer agent and a derivative of Exatecan. It exhibits significant antitumor activity and is suitable for research on various cancers, including solid tumors.
- Derivative of Exatecan
- Anticancer agent
- Exhibits significant antitumor activity
- Suitable for research on various cancers
- Can be used for solid tumors research
Medchemexpress LLC Eteplirsen | 1173755-55-9 | 98.5% | 10306.00 | 1 ML
Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide. It is used for Duchenne muscular dystrophy research. It promotes dystrophin production by restoring the translational reading frame of Duchenne muscular dystrophy (DMD) through specific skipping of exon 51 in defective gene variants.
- Synthetic antisense oligonucleotide
- Can be used for Duchenne muscular dystrophy research
- Promotes dystrophin production by restoring the translational reading frame through specific skipping of exon 51